GETTING MY PKRRATING TO WORK

The activated enzyme then phosphorylates its key substrate, the translational initiation variable eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs into a conserved loved ones of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in response to different stimuli12, triggering the integrated str